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Related Concept Videos

Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
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Related Experiment Video

Updated: Jun 26, 2026

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
07:51

Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Published on: May 21, 2015

[Anti-CD10 fetomaternal alloimmunisation].

Pierre Ronco1, Hanna Debiec, Vincent Guigonis

  • 1Unité Inserm UMR S 702, UPMC Université Paris 6, Assistance Publique-Hôpitaux de Paris, Hôpital Tenon, Paris, France. pierre.ronco@tnn.aphp.fr

Medecine Sciences : M/S
|January 22, 2009
PubMed
Summary
This summary is machine-generated.

Fetomaternal alloimmunization causes fetal kidney disease due to antibodies against neutral endopeptidase (NEP). Identifying NEP epitopes is crucial for diagnosing and treating this antenatal glomerulopathy.

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Published on: May 21, 2015

Measurement of T Cell Alloreactivity Using Imaging Flow Cytometry
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Isolation of Leukocytes from the Human Maternal-fetal Interface
08:19

Isolation of Leukocytes from the Human Maternal-fetal Interface

Published on: May 21, 2015

Area of Science:

  • Immunology
  • Nephrology
  • Reproductive Medicine

Context:

  • Fetomaternal alloimmunization with antenatal glomerulopathies (FMAIG) is a newly identified alloimmune disorder.
  • Maternal antibodies target fetal glomerular podocytes, leading to renal disease.
  • Pathogenic antibodies are directed against CD10/neutral endopeptidase (NEP).

Purpose:

  • To identify pathogenic epitopes of CD10/neutral endopeptidase (NEP) involved in FMAIG.
  • To develop diagnostic tests (ELISA) and therapeutic strategies for FMAIG.
  • To establish an experimental mouse model for studying NEP alloimmunization and tolerance induction.

Summary:

  • Mothers deficient in NEP become immunized against fetal NEP during pregnancy, producing pathogenic antibodies.
  • These antibodies cross the placenta, bind to fetal podocytes, and cause antenatal glomerulopathy.
  • Characterized NEP epitopes will enable diagnostic assays and peptide-specific immune interventions.

Impact:

  • Urgent need for detection of anti-NEP antibodies and antigen-driven therapies to prevent fetal renal disease.
  • Identified epitopes are key for developing diagnostic tests and novel therapeutic approaches.
  • Findings may also shed light on de novo membranous nephropathy in kidney grafts and after bone marrow transplantation.