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Related Concept Videos

Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
Pleiotropy01:33

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
General Transcription Factors01:30

General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...

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Related Experiment Video

Updated: Jun 26, 2026

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
10:10

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries

Published on: March 31, 2019

[Hoxa5: a master gene with multifaceted roles].

Olivier Boucherat1, François Guillou, Josée Aubin

  • 1Centre de recherche en cancérologie de l'Université Laval, Centre Hospitalier Universitaire de Québec, L'Hôtel-Dieu de Québec, 9, rue McMahon, Québec G1R 2J6, Canada.

Medecine Sciences : M/S
|January 22, 2009
PubMed
Summary

The Hoxa5 gene is crucial for embryonic development, particularly in forming the respiratory tract, digestive system, and glands. Its dysregulation is linked to cancer and leukemia.

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HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
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Prediction and Validation of Gene Regulatory Elements Activated During Retinoic Acid Induced Embryonic Stem Cell Differentiation
09:07

Prediction and Validation of Gene Regulatory Elements Activated During Retinoic Acid Induced Embryonic Stem Cell Differentiation

Published on: June 21, 2016

Area of Science:

  • Developmental Biology
  • Genetics
  • Molecular Biology

Context:

  • Hox genes are essential for embryonic body patterning and morphogenesis.
  • Understanding Hox gene regulation and function remains a significant challenge in developmental biology.
  • Hoxa5, a member of the Hox gene family, plays a critical role in embryonic development.

Purpose:

  • To provide an overview of the current knowledge regarding the function and regulation of the Hoxa5 gene.
  • To highlight the crucial role of Hoxa5 in embryonic morphogenesis and regional identity specification.
  • To explore the implications of Hoxa5 in both normal development and disease, including cancer.

Summary:

  • Hoxa5 mutant mice exhibit severe defects in respiratory tract development, leading to high mortality at birth.
  • Surviving Hoxa5 mutants show impaired lung alveolarization and defects in the digestive tract, thyroid, and mammary glands.
  • Hoxa5 regulates organogenesis through mesenchymal-epithelial interactions and its dysregulation is implicated in tumorigenesis, affecting genes like p53 and influencing leukemia development.

Impact:

  • This research underscores the critical role of Hoxa5 in mammalian development and organogenesis.
  • The findings suggest Hoxa5 as a potential target for understanding and treating developmental disorders and cancers.
  • Understanding Hoxa5 regulation provides insights into the broader importance of Hox gene cluster organization for proper gene function.