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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
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Tract-based morphometry for white matter group analysis.

Lauren J O'Donnell1, Carl-Fredrik Westin, Alexandra J Golby

  • 1Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston MA, USA. odonnell@bwh.harvard.edu

Neuroimage
|January 22, 2009
PubMed
Summary

Tract-based morphometry (TBM) analyzes diffusion MRI data along white matter tracts. This method reveals subtle interhemispheric diffusion differences in the arcuate fasciculus and cingulum bundle, enhancing neuroanatomical analysis.

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Area of Science:

  • Neuroimaging
  • Diffusion MRI Analysis
  • Computational Neuroscience

Background:

  • Diffusion MRI data analysis traditionally uses scalar invariants, potentially missing localized tract variations.
  • White matter tract morphometry requires robust methods for cross-subject and cross-hemisphere comparisons.

Purpose of the Study:

  • Introduce tract-based morphometry (TBM) for analyzing diffusion MRI data along white matter tracts.
  • Develop an improved optimal match method to reduce spatial distortion and variability in fractional anisotropy (FA) measurements.
  • Investigate interhemispheric diffusion asymmetries in the arcuate fasciculus (AF) and cingulum bundle (CB) using TBM.

Main Methods:

  • Subject-specific tractography bundle segmentations were used to generate arc length parameterization with point correspondences.
  • An improved optimal match method was developed and quantitatively compared with existing fiber coordinate systems.
  • Arc length correspondences across hemispheres were generated for TBM studies of interhemispheric asymmetries.

Main Results:

  • TBM detected differences not apparent with mean scalar invariant measurements, such as mean diffusivity (MD) in the AF.
  • Higher fractional anisotropy (FA) was observed in the left hemisphere AF, linked to lower lambda(3) of the diffusion tensor.
  • Higher left hemisphere FA was found in the CB, associated with higher lambda(1) of the diffusion tensor.

Conclusions:

  • Tract-based morphometry (TBM) provides a framework for analyzing diffusion tensor imaging (DTI) data within the context of tract anatomy.
  • TBM enables the detection of localized diffusion differences and interhemispheric asymmetries, offering clinically and neuroanatomically relevant insights.
  • The study demonstrates TBM's capability to reveal subtle variations in white matter microstructure across hemispheres.