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Operating and Biocontainment Procedures of a Facility for Laboratory Mice with a Natural Microbiome: Immunophenotyping Procedure
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Operating and Biocontainment Procedures of a Facility for Laboratory Mice with a Natural Microbiome: Immunophenotyping Procedure

Published on: December 13, 2024

The caBIG terminology review process.

James J Cimino1, Terry F Hayamizu, Olivier Bodenreider

  • 1National Institutes of Health, Laboratory for Informatics Development, Clinical Center, Room 6-2551, 10 Center Drive, Bethesda, MD 20892, USA. ciminoj@mail.nih.gov

Journal of Biomedical Informatics
|January 22, 2009
PubMed
Summary
This summary is machine-generated.

The National Cancer Institute developed criteria to evaluate biomedical terminologies for cancer research informatics. These criteria assess structure, content, and editorial processes, aiding data standardization efforts.

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Last Updated: Jun 26, 2026

Operating and Biocontainment Procedures of a Facility for Laboratory Mice with a Natural Microbiome: Immunophenotyping Procedure
05:34

Operating and Biocontainment Procedures of a Facility for Laboratory Mice with a Natural Microbiome: Immunophenotyping Procedure

Published on: December 13, 2024

Area of Science:

  • Biomedical Informatics
  • Cancer Research
  • Data Standardization

Background:

  • The National Cancer Institute (NCI) is creating the cancer Biomedical Informatics Grid (caBIG) to foster collaboration among cancer researchers.
  • Standardized terminology is crucial for data representation within the caBIG architecture.

Purpose of the Study:

  • To develop and apply criteria for evaluating the suitability of controlled terminologies for biomedical informatics.
  • To assess the evolution and application of these criteria in the context of caBIG.

Main Methods:

  • The caBIG Vocabulary and Data Elements Workspace (VCDE WS) working group established criteria evaluating terminology structure, content, documentation, and editorial processes.
  • These criteria were used to evaluate four standard terminologies: Gene Ontology (GO), NCI Thesaurus (NCIt), Common Terminology for Adverse Events (CTCAE), and Logical Objects, Identifiers, Names and Codes (LOINC).

Main Results:

  • The paper details the development of caBIG criteria for terminology evaluation.
  • The application of these criteria to GO, NCIt, CTCAE, and LOINC is presented.
  • A resulting matrix of caBIG criteria is offered for broader use in terminology standardization.

Conclusions:

  • The developed caBIG criteria provide a framework for assessing controlled terminologies in biomedical informatics.
  • The evaluation of existing terminologies highlights their strengths and potential areas for improvement.
  • The caBIG criteria matrix can support future terminology standardization initiatives in cancer research and beyond.