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Papillary Dermis

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
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Reticular Dermis

Reticular Dermis

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Reticular Layer
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Cells of the Epidermis

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Related Experiment Video

Updated: Jun 26, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

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Signet-ring cell dermatofibroma.

M C Garrido-Ruiz¹, R Carrillo, A B Enguita

¹Department of Pathology, 12 de Octubre University Hospital, Madrid, Spain.

The American Journal of Dermatopathology

|January 22, 2009

Summary

This summary is machine-generated.

A new variant of dermatofibroma, the signet-ring cell dermatofibroma, has been identified. This rare benign skin lesion exhibits unique histologic features, expanding the known spectrum of cutaneous fibrous histiocytoma.

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Area of Science:

Dermatopathology
Oncology

Background:

Dermatofibroma, a common benign skin neoplasm, presents with diverse histologic variants.
While generally benign, some variants like cellular and aneurysmal dermatofibromas have a propensity for local recurrence and, rarely, metastasis.

Observation:

Signet-ring cells, typically associated with metastatic adenocarcinoma, are characterized by cytoplasmic inclusions displacing the nucleus.
Their presence in primitive cutaneous neoplasms is documented, but they have not been previously described in dermatofibroma.

Findings:

This report details the first case of a signet-ring cell dermatofibroma in a 16-year-old male.
Histologic examination revealed a fibrohistiocytic proliferation with a prominent signet-ring cell morphology.
Histochemical and immunohistochemical analyses confirmed the diagnosis of dermatofibroma.

Implications:

The identification of signet-ring cell dermatofibroma broadens the histologic classification of cutaneous fibrous histiocytoma.
This variant poses significant differential diagnostic challenges, particularly in distinguishing it from metastatic adenocarcinoma.