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Possible involvement of nitric oxide in long-term potentiation
G A Böhme1, C Bon, J M Stutzmann
1Rhône-Poulenc Rorer, Centre de Recherches de Vitry-Alfortville, Vitry-sur-Seine, France.
European Journal of Pharmacology
|July 9, 1991
Abstract:
Long-term potentiation (LTP) in the hippocampus is known to involve NMDA (N-methyl-D-aspartate) receptors. Since activation of NMDA receptors in the cerebellum results in the formation of nitric oxide (NO), we studied the possible involvement of this messenger in hippocampal synaptic plasticity. We report here that the NO-synthase inhibitor, L-N omega-nitro-arginine, blocks LTP and that sodium nitroprusside, which releases NO, produces a long-lasting enhancement in synaptic efficacy which is not additive with tetanus-induced LTP.