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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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Related Experiment Video

Updated: Jun 26, 2026

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
08:48

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Published on: January 29, 2016

Treadmill exercise in early mutiple sclerosis: a case series study.

M G Benedetti1, V Gasparroni, S Stecchi

  • 1Movement Analysis Laboratory Rizzoli Orthopedic Institute University of Bologna, Bologna, Italy. benedetti@ior.it

European Journal of Physical and Rehabilitation Medicine
|January 22, 2009
PubMed
Summary
This summary is machine-generated.

Aerobic treadmill exercise is a feasible and safe intervention for improving early balance and walking impairments in multiple sclerosis (MS) patients. This study demonstrated improvements in postural stability and normalized muscular activity patterns.

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Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Exercise Physiology

Background:

  • Balance and walking disorders are common in multiple sclerosis (MS), impacting patient mobility and quality of life.
  • The efficacy of specific exercise therapies for managing these MS-related deficits requires further investigation with reproducible measurement systems.

Purpose of the Study:

  • To assess the feasibility and effects of an aerobic treadmill rehabilitation protocol (endurance training) on walking parameters, muscular activity, and postural balance in minimally impaired MS patients.
  • To utilize instrumental measures to detect minimal motor dysfunction not apparent in standard clinical examinations.

Main Methods:

  • A case series involving three minimally impaired MS patients undergoing a four-week aerobic treadmill endurance training program.
  • Outcome measures included posturographic assessment, energy cost measurement, gait analysis (basography), and surface electromyography.

Main Results:

  • Reduced energy cost during treadmill walking was observed in all three patients post-exercise.
  • Postural stability, measured by sway path and area, improved in two patients, especially with eyes closed.
  • Gait patterns showed minor changes in foot placement, and muscular activity patterns tended to normalize after training.

Conclusions:

  • Aerobic treadmill exercise is a feasible and safe rehabilitation strategy for early-stage MS patients with minimal impairment.
  • The proposed instrumental measurement set can identify subclinical postural and gait anomalies in individuals with very low functional involvement.
  • This approach supports an impairment-oriented rehabilitation strategy for MS.