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Altered cell function in microgravity.

M Hughes-Fulford1

  • 1University of California Medical Center, San Francisco.

Experimental Gerontology
|January 1, 1991
PubMed
Summary
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Spaceflight alters fundamental cellular functions in all life forms, mirroring physiological changes seen in aging humans. This research explores microgravity

Area of Science:

  • Space biology
  • Cellular physiology
  • Human physiology

Background:

  • Spaceflight induces significant physiological alterations in humans and other organisms.
  • Studies on Skylab, SL-3, and D-1 missions reveal changes in single-cell organisms and animal tissues.
  • Microgravity affects basic cellular functions like electrolyte balance, growth, and metabolism.

Purpose of the Study:

  • To investigate the impact of microgravity on fundamental biological mechanisms.
  • To explore the parallels between spaceflight-induced physiological changes and human aging.
  • To leverage spaceflight research for insights into essential life processes.

Main Methods:

  • Analysis of physiological data from human spaceflight missions (Skylab, SL-3, D-1).
Keywords:
NASA Discipline Cell BiologyNASA Discipline Number 40-20NASA Program Space BiologyNon-NASA Center

Related Experiment Videos

  • Examination of cellular and tissue alterations in microgravity.
  • Comparative analysis of spaceflight effects and aging-related physiological changes.

    • Main Results:

    • Microgravity modifies basic cellular functions, including electrolyte concentration, cell growth, glucose utilization, bone formation, and exocytosis.
    • Physiological changes observed in spaceflight are shared by humans, vertebrates, and simpler organisms.
    • Aging humans exhibit symptoms similar to those experienced by astronauts, such as reduced cardiac function and bone loss.

    Conclusions:

    • Microgravity-induced dysfunction of basic biological mechanisms may underlie many physiological changes observed in spaceflight.
    • Aging and spaceflight adaptations may share common physiological underpinnings at the subcellular and molecular levels.
    • Space exploration provides a unique model for understanding fundamental biological mechanisms essential for life.