The pituitary: aging and spaceflown rats

Decrements in growth hormone (GH) release we observed in two spaceflight experiments and four tail-suspended rat studies mimic age-associated changes in the mammalian pituitary GH system seen by Meites and others. The spaceflight data suggest that formation of high molecular weight bioactive disulfide-linked aggregates of the 20 and 22K monomeric GH forms may be reduced in microgravity, thereby, reducing target tissue activity. Correlative studies to confirm spaceflight as a model for pituitary GH system aging should include: 1) investigation of mechanisms of intracellular hormone packaging, 2) consequences to biological activity of the hormone molecule, and 3) study of intracellular microtubule dynamics.