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Mapping the epigenome--impact for toxicology

Jennifer Marlowe1, Soon-Siong Teo, Salah-Dine Chibout

  • 1Novartis Pharma AG, Investigative Toxicology, Preclinical Safety, Basel, Switzerland. jennifer.marlowe@novartis.com

EXS
|January 23, 2009
PubMed

Insights

Technological advances in epigenome mapping offer new ways to study how epigenetic modifications link to human diseases and drug effectiveness. These epigenomic profiling tools can reveal long-lasting cellular changes relevant to drug safety and disease susceptibility.

Area of Science:

  • Epigenetics and Drug Safety Science

Background:

  • Recent technological advancements enable detailed epigenome mapping and characterization.
  • Epigenetic modifications are increasingly linked to human diseases and drug targets.
  • Xenobiotic-induced epigenetic changes are well-studied in non-genotoxic carcinogenesis.

Purpose of the Study:

  • To explore the relationship between epigenetic modifications, human diseases, and pharmaceutical drug potential.
  • To highlight the application of epigenomic profiling in drug safety sciences.
  • To investigate the molecular basis of long-lasting cellular perturbations.

Main Methods:

  • Utilizing advanced technological approaches for epigenome mapping.
  • Characterizing the epigenome to understand its role in disease.
  • Applying epigenomic profiling technologies to drug safety studies.

Main Results:

  • New opportunities arise for studying epigenetics in relation to disease and drug therapies.
  • Growing evidence supports the role of epigenetic mechanisms in various disease areas.
  • Epigenomic profiling offers insights into cellular memory and transgenerational effects.

Conclusions:

  • Epigenomic profiling technologies have significant potential in drug safety sciences.
  • Understanding epigenetic perturbations is crucial for addressing disease susceptibility and toxicity.
  • These technologies can illuminate the molecular underpinnings of long-term cellular responses to exposures.

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