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Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
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[Hereditary neuropathies].

Jean-Michel Vallat1, Judith Calvo, Karima Ghorab

  • 1Service de neurologie, centre de référence neuropathies périphériques rares, CHU Dupuytren, 87042 Limoges Cedex, France. jean-michel.vallat@unilim.fr

La Revue Du Praticien
|January 23, 2009
PubMed
Summary
This summary is machine-generated.

Hereditary neuropathies, excluding Charcot-Marie-Tooth disease, are rare genetic disorders. Diagnosis is challenging, especially for sporadic forms, and specific gene repair treatments are not yet available.

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Last Updated: Jun 26, 2026

In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration
06:35

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Published on: June 15, 2018

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In Vivo Electrophysiological Measurement of the Rat Ulnar Nerve with Axonal Excitability Testing

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Area of Science:

  • Neurology
  • Genetics

Context:

  • Hereditary neuropathies encompass a diverse group of rare genetic disorders affecting the peripheral nervous system.
  • Transmission patterns include autosomal dominant, autosomal recessive, and X-linked inheritance.
  • Sporadic forms present diagnostic challenges, distinct from inherited conditions.

Purpose:

  • To provide a structured overview of human hereditary neuropathies.
  • To highlight the diagnostic complexities and genetic underpinnings.
  • To acknowledge the current limitations in specific gene-targeted therapies.

Summary:

  • Most hereditary neuropathies, apart from Charcot-Marie-Tooth disease (hereditary sensorimotor neuropathy), are rare.
  • These conditions exhibit varied inheritance patterns (autosomal dominant, recessive, X-linked).
  • Distinguishing between neuropathies as sole clinical manifestations and those within multisystemic diseases is crucial.

Impact:

  • Understanding the genetic complexity and functional roles of involved genes is essential for classification and future research.
  • Current therapeutic strategies focus on symptomatic management due to the absence of gene-specific repair treatments.