Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmaceutical Poisoning: Treatment Strategies01:26

Pharmaceutical Poisoning: Treatment Strategies

Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...
Drug Toxicity: Dose-Dependent Reactions01:24

Drug Toxicity: Dose-Dependent Reactions

Drug toxicities can be stratified into pharmacological, pathological, or genotoxic based on their mechanisms. The incidence and severity of these toxicities generally increase with the drug's concentration in the body and exposure time.Pharmacological toxicity is evident when the therapeutic effects of drugs overshoot into adverse reactions in a predictable, dose-dependent manner. Central nervous system (CNS) depression from barbiturates is a classic example, with effects escalating from...
Prevention of Further Absorption of Poison01:14

Prevention of Further Absorption of Poison

In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
Drug Toxicity: Risk factors01:24

Drug Toxicity: Risk factors

Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
Anticholinesterase Agents: Poisoning and Treatment01:26

Anticholinesterase Agents: Poisoning and Treatment

Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.     
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is slower than the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of biometals in activation of immune cum inflammatory response in ovine ageing eye: a potential model for understanding human geriatric eye diseases.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine·2021
Same author

Woodhouse-Sakati syndrome in a family is associated with a homozygous start loss mutation in the DCAF17 gene.

Clinical and experimental dermatology·2019
Same author

Novel autosomal recessive LAMA3 and PLEC variants underlie junctional epidermolysis bullosa generalized intermediate and epidermolysis bullosa simplex with muscular dystrophy in two consanguineous families.

Clinical and experimental dermatology·2018
Same author

Homozygous SLCO2A1 translation initiation codon mutation in a Pakistani family with recessive isolated congenital nail clubbing.

The British journal of dermatology·2016
Same author

A novel deletion mutation in the DSG4 gene underlies autosomal recessive hypotrichosis with variable phenotype in two unrelated consanguineous families.

Clinical and experimental dermatology·2014
Same author

Aberrant TGF-β signaling underlies the pathogenesis of aortic aneurysm in Shprintzen-Goldberg syndrome.

Clinical genetics·2013
Same journal

Evaluating the completeness of perioperative outcome metrics in electronic medical records: Insights based on the proposed Perioperative Clinical Outcomes Registry framework.

Anaesthesia and intensive care·2026
Same journal

Large language model prompt engineering for medical education: A practical guide for the Australian and New Zealand College of Anaesthetists Final Examination.

Anaesthesia and intensive care·2026
Same journal

Nitrous oxide added at the end of sevoflurane anaesthesia hastens emergence and eliminates prolonged time to extubation (SEVONATE study): A randomised controlled trial.

Anaesthesia and intensive care·2026
Same journal

Complications related to arterial line catheters and monitoring reported to webAIRS, 2009-2023.

Anaesthesia and intensive care·2026
Same journal

A summary guide for detecting and reducing nitrous oxide infrastructure leaks in healthcare facilities.

Anaesthesia and intensive care·2026
Same journal

Is jelly a solid or a clear liquid? A pilot study using ultrasound to assess the gastric emptying of fruit-flavoured gelatin dessert.

Anaesthesia and intensive care·2026
See all related articles

Related Experiment Video

Updated: Jun 26, 2026

Generation and Long-term Maintenance of Nerve-free Hydra
06:33

Generation and Long-term Maintenance of Nerve-free Hydra

Published on: July 7, 2017

Survival after massive hydroxychloroquine overdose.

N Gunja1, D Roberts, D McCoubrie

  • 1New South Wales Poisons Information Centre, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.

Anaesthesia and Intensive Care
|January 23, 2009
PubMed
Summary
This summary is machine-generated.

Two patients survived massive hydroxychloroquine overdose (20g) with advanced cardiac life support, including sodium bicarbonate, adrenaline, and potassium. Aggressive treatment led to rapid recovery from cardiovascular collapse without lasting effects.

More Related Videos

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
09:44

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen

Published on: November 27, 2019

Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness
09:17

Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness

Published on: May 2, 2017

Related Experiment Videos

Last Updated: Jun 26, 2026

Generation and Long-term Maintenance of Nerve-free Hydra
06:33

Generation and Long-term Maintenance of Nerve-free Hydra

Published on: July 7, 2017

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
09:44

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen

Published on: November 27, 2019

Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness
09:17

Use of a Central Venous Line for Fluids, Drugs and Nutrient Administration in a Mouse Model of Critical Illness

Published on: May 2, 2017

Area of Science:

  • Toxicology
  • Cardiology
  • Emergency Medicine

Background:

  • Hydroxychloroquine overdose is rare, with limited specific treatment guidelines.
  • Existing recommendations often extrapolate from chloroquine poisoning data.
  • Massive hydroxychloroquine poisoning requires advanced medical intervention.

Observation:

  • Two cases of severe hydroxychloroquine poisoning (20g each) were reported.
  • Patients experienced rapid deterioration and cardiovascular collapse.
  • Highest recorded non-lethal serum concentrations were observed (13.8 and 26.0 mg/l).

Findings:

  • Both patients received advanced cardiac life support and a specific treatment regimen.
  • Treatment included sodium bicarbonate, adrenaline, and potassium administration.
  • Aggressive correction of electrolyte and pH disturbances was crucial.

Implications:

  • Successful survival from massive hydroxychloroquine overdose is possible with prompt, aggressive management.
  • Rapid drug distribution to peripheral tissues aids recovery.
  • This case series provides valuable insights into managing severe hydroxychloroquine toxicity.