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07:25
Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice
Published on: September 25, 2019
[Therapy of chronic hepatitis B]
1Hospital General Universitario Vall d'Hebrón de Barcelona, Barcelona, España. mbuti@vhebron.net
Acta Gastroenterologica Latinoamericana
|January 23, 2009
Summary
New oral antiviral therapies and interferon have expanded chronic hepatitis B treatment options, even for advanced liver disease. Preventing drug resistance remains a key challenge to avoid disease progression and complications.
Area of Science:
- Hepatology
- Virology
- Pharmacology
Context:
- Chronic Hepatitis B (CHB) management has evolved with novel oral antiviral agents.
- Interferon (standard and pegylated) remains part of the therapeutic armamentarium for CHB.
- Oral antivirals include lamivudine, adefovir, entecavir, telbivudine, and tenofovir.
Purpose:
- To review the current therapeutic landscape for Chronic Hepatitis B.
- To highlight the expanded indications for CHB treatment.
- To address the challenge of antiviral drug resistance.
Summary:
- The introduction of oral antivirals (lamivudine, adefovir, entecavir, telbivudine, tenofovir) and interferons has broadened treatment options for Chronic Hepatitis B.
- These advancements allow for the management of patients with advanced and decompensated liver disease.
- A significant limitation is the emergence of drug-resistant Hepatitis B Virus (HBV) strains.
Impact:
- Expanded therapeutic options improve outcomes for patients with advanced liver disease.
- Preventing HBV drug resistance is crucial for sustained viral suppression.
- Effective management aims to halt liver disease progression and prevent HBV-related complications.
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