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Updated: Jun 26, 2026

Source and Route of Pyrrolizidine Alkaloid Contamination in Tea Samples
Published on: September 28, 2022
Cyanogenic and non-cyanogenic pyridone glucosides from Acalypha indica (Euphorbiaceae)
Monika Hungeling1, Matthias Lechtenberg, Frank R Fronczek
1Institute of Pharmaceutical Biology and Phytochemistry, Westfälische Wilhelms-Universität, Hittorfstrasse 56, D-48149 Münster, Germany.
Abstract:
Seven cyanopyridone derivatives and one corresponding seco compound have been isolated from a methanolic extract of the inflorescences and leaves of Acalypha indica L. (Euphorbiaceae). The absolute configuration of the main cyanogenic glucoside acalyphin, (-)-(5R,6S)-5-cyano-5-beta-d-glucopyranosyloxy-6-hydroxy-4-methoxy-1-methyl-2(5,6-dihydro)-pyridone, was deduced from an X-ray crystallographic study. In addition, the 6R-epimer of acalyphin, epiacalyphin, and the corresponding pair of N-demethyl derivatives were isolated. The corresponding amide of acalyphin and a 1',2'-glucosyl-fused epiacalyphin amide were isolated from air-dried material. Structural elucidation was performed by means of (1)H and (13)C NMR-spectra, chiroptical methods such as CD-spectroscopy and optical rotation. Two further corresponding derivatives, an aromatized compound and an open-chain structure, were isolated from the aqueous phase.
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