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Updated: Jun 26, 2026

Protocol to Create Chronic Wounds in Diabetic Mice
Published on: September 25, 2019
[Postoperative wound healing disorders]
Gábor Bartos1, Gabriella Markovics, Tamás Várföldi
1Szent Pantaleon Kórház Altalános Sebészeti Osztály Dunaújváros Tamási Aron u. 43. 2400. med-ister@chello.hu
This study analyzed 33,336 operations, finding wound healing disorders occurred at 2.2% and surgical site infections at 2.7%. Both rates decreased over 20 years, with wound healing disorders potentially serving as a new surgical quality indicator.
Area of Science:
- Surgical Outcomes
- Infection Control
- Healthcare Quality Assurance
Background:
- Wound healing disorders and surgical site infections (SSIs) are critical metrics in surgical outcomes.
- Standardized nomenclature and surveillance systems are essential for accurate data collection.
- The relationship between wound healing disorders and SSI risk stratification requires further investigation.
Purpose of the Study:
- To investigate the incidence of wound healing disorders and their correlation with nosocomial operation categories and registered surgical site infections.
- To analyze trends in wound healing disorders and SSIs over a 20-year period.
- To explore the potential of wound healing disorders as indicators for surgical quality assurance.
Main Methods:
- Analysis of data from 33,336 operations over 20 years.
- Prospective registration of wound healing disorders and case histories.
- Categorization of operations based on nosocomial risk (A-D) and comparison with SSI rates.
- Monthly and long-term summarization of disorder and infection data.
Main Results:
- The 20-year summarized incidence rates were 2.2% for wound healing disorders and 2.7% for surgical site infections.
- Both wound healing disorders and SSIs showed diminishing rates in the latter half of the observation period.
- A significant correlation was observed: as SSI rates increased with operation category (A-D), so did wound healing disorder rates, though generally to a lesser extent.
Conclusions:
- Wound healing disorders and SSIs exhibit a complex, inversely related pattern when SSI rates are above or below 2%.
- Wound healing disorders may represent 'loci minoris resistentiae' that can either suppurate or not, depending on the operation's septic category.
- Wound healing disorder rates could potentially serve as novel indicators for evaluating and assuring surgical quality.
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