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Localization, Identification, and Excision of Murine Adipose Depots
Published on: December 4, 2014
Adipose tissue distribution is different in type 2 diabetes.
Dympna Gallagher1, David E Kelley, Jung-Eun Yim
1Body Composition Unit-New York Obesity Research Center, St Luke's-Roosevelt Hospital, 1111 Amsterdam Avenue, Scrymser Basement, New York, NY 10025, USA. dg108@columbia.edu
The American Journal of Clinical Nutrition
|January 23, 2009
Summary
Individuals with type 2 diabetes (T2DM) exhibit distinct adipose tissue (AT) distribution, characterized by less subcutaneous AT (SAT) and more visceral AT (VAT) and intermuscular AT (IMAT) compared to healthy individuals. This altered AT distribution may exacerbate insulin resistance.
Area of Science:
- Endocrinology
- Metabolic Diseases
- Medical Imaging
Background:
- Adipose tissue (AT) distribution differences between type 2 diabetes (T2DM) and non-diabetic individuals are not well understood.
- Understanding these differences is crucial for managing T2DM complications.
Purpose of the Study:
- To investigate whether total body adiposity and its distribution differ between individuals with T2DM and healthy controls.
- To quantify these differences using advanced whole-body magnetic resonance imaging (MRI).
Main Methods:
- A cross-sectional study involving 93 participants with T2DM and 93 healthy controls.
- Whole-body MRI was used to measure total-body AT (TAT), subcutaneous AT (SAT), visceral AT (VAT), and intermuscular AT (IMAT).
- Linear regression models adjusted for race, sex, age, height, and weight.
Main Results:
- Individuals with T2DM had significantly less SAT (including femoral-gluteal SAT) compared to controls.
- T2DM participants showed significantly more VAT and IMAT than healthy controls.
- These differences were consistent across different ancestries.
Conclusions:
- Adipose tissue distribution is significantly altered in T2DM.
- Increased VAT and IMAT, along with decreased SAT, are characteristic of T2DM.
- This altered AT distribution may contribute to and compound insulin resistance in T2DM patients.
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