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Low bone volume--a risk factor for coronary calcifications in hemodialysis patients

Teresa Adragao1, Johann Herberth, Marie-Claude Monier-Faugere

  • 1Nephrology Department, Santa Cruz Hospital, Lisbon, Portugal.

Clinical Journal of the American Society of Nephrology : CJASN
|January 23, 2009
PubMed

Insights

Low bone volume is linked to higher coronary calcifications in hemodialysis patients. This association is significant in early years of dialysis but diminishes over time.

Area of Science:

  • Nephrology
  • Cardiology
  • Bone Metabolism

Background:

  • Altered bone metabolism is increasingly linked to cardiovascular calcifications in stage 5 chronic kidney disease patients undergoing hemodialysis.
  • Understanding this relationship is crucial for managing cardiovascular risk in this population.

Purpose of the Study:

  • To investigate the association between bone volume, bone turnover, and coronary artery calcifications in hemodialysis patients.

Main Methods:

  • A cross-sectional study involving 38 hemodialysis patients.
  • Bone biopsies analyzed via histomorphometry to assess bone volume and turnover.
  • Multislice computed tomography used to quantify coronary calcifications via Agatston scores.

Main Results:

  • 50% of patients exhibited low bone turnover, and 16% had low bone volume.
  • Lower bone volume was a significant predictor of coronary calcifications in patients with early years of hemodialysis (duration < 6 years).
  • Bone turnover parameters were not significantly associated with coronary calcifications.

Conclusions:

  • Low bone volume is associated with increased coronary calcifications in hemodialysis patients.
  • The impact of low bone volume on coronary calcifications appears more pronounced in the initial years of hemodialysis treatment.
Abstract

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