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MoisturePlus contact lens solution as a source of acanthamoeba keratitis
Simon Hasler1, Wasiliki Dedes, Alexander Mathis
1Department of Ophthalmology, Kantonsspital Lucerne, Lucerne, Switzerland. sih@gmx.net
Cornea
|January 23, 2009
Summary
Advanced Medical Optics Complete MoisturePlus solution was linked to Acanthamoeba keratitis. Researchers traced an Acanthamoeba keratitis case back to this contact lens solution, confirming the link.
Area of Science:
- Ophthalmology
- Microbiology
- Molecular Biology
Background:
- Acanthamoeba keratitis (AK) is a serious eye infection.
- The Advanced Medical Optics (AMO) Complete MoisturePlus multipurpose solution was suspected as a risk factor for AK.
- AMO voluntarily recalled this solution in May 2007.
Observation:
- A patient diagnosed with Acanthamoeba keratitis used the AMO Complete MoisturePlus solution.
- The specific strain of Acanthamoeba from the patient's eye was analyzed.
Findings:
- Polymerase chain reaction (PCR) amplification and gene sequencing were used.
- The 18S rRNA gene of the Acanthamoeba isolate was sequenced.
- The genetic analysis successfully linked the Acanthamoeba isolate from the patient to the AMO Complete MoisturePlus solution.
Implications:
- This study provides the first direct molecular evidence linking a specific contact lens solution to Acanthamoeba keratitis.
- Confirms the etiological role of AMO Complete MoisturePlus in AK cases.
- Highlights the importance of rigorous testing and monitoring of contact lens care products.
