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Two proteins act as the IUF1 insulin gene enhancer binding factor
V Scott1, A R Clark, J C Hutton
1Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, UK.
FEBS Letters
|September 23, 1991
Abstract:
IUF1 is a pancreatic beta cell-specific factor which binds to the sequence 5'-CPyCTAATG-3' (CT box) within the human insulin gene enhancer. Here we show that IUF1 is composed of 2 binding activities that can be separated by DEAE ion exchange chromatography. South Western blot analysis indicates that these distinct binding activities have apparent molecular weights of 115 kDa and 46 kDa.