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Related Concept Videos

MAPK Signaling Cascades01:07

MAPK Signaling Cascades

Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
DNA Damage can Stall the Cell Cycle02:36

DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
DNA Damage Can Stall the Cell Cycle02:36

DNA Damage Can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
Inhibition of CDK Activity02:34

Inhibition of CDK Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...

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Related Experiment Video

Updated: Jun 26, 2026

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
12:02

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

Non-classical p38 map kinase functions: cell cycle checkpoints and survival.

Tina M Thornton1, Mercedes Rincon

  • 1Department of Medicine/Immunobiology Program, University of Vermont, Burlington, Vermont 05405-0068, USA.

International Journal of Biological Sciences
|January 23, 2009
PubMed
Summary

The p38 mitogen-activated protein kinase (MAPK) pathway regulates cell cycle checkpoints and survival. While often linked to cell death, p38 MAPK also promotes cell survival, particularly after DNA damage, impacting therapeutic strategies.

Keywords:
Cell Cycle CheckpointSurvivalp38 MAPK

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Analysis of Cell Cycle Position in Mammalian Cells
12:19

Analysis of Cell Cycle Position in Mammalian Cells

Published on: January 21, 2012

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Last Updated: Jun 26, 2026

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
12:02

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

Analysis of Cell Cycle Position in Mammalian Cells
12:19

Analysis of Cell Cycle Position in Mammalian Cells

Published on: January 21, 2012

Area of Science:

  • Cellular Biology
  • Molecular Signaling
  • Stress Response

Background:

  • The p38 MAPK pathway is a critical signaling cascade activated by diverse cellular stressors and cytokines.
  • Established roles of p38 MAPK include mediating cell differentiation and apoptosis.
  • Less explored functions involve cell cycle regulation and survival pathways.

Purpose of the Study:

  • To elucidate the role of p38 MAPK in cell cycle checkpoint control.
  • To investigate the dual role of p38 MAPK in mediating both cell death and cell survival.
  • To highlight underappreciated functions of p38 MAPK in cellular stress responses.

Main Methods:

  • Review of existing literature on p38 MAPK signaling.
  • Analysis of p38 MAPK's involvement in G1/S and G2/M cell cycle checkpoints.
  • Discussion of p38 MAPK's context-dependent effects on cell survival and apoptosis.

Main Results:

  • p38 MAPK actively regulates both G1/S and G2/M cell cycle checkpoints in response to cellular stress, including DNA damage.
  • Contrary to its classical association with apoptosis, p38 MAPK can promote cell survival under specific conditions, such as following DNA damage.
  • These findings reveal a more nuanced understanding of p38 MAPK's functions.

Conclusions:

  • p38 MAPK plays a significant role in cell cycle regulation and exhibits context-dependent effects on cell survival.
  • Recognizing the pro-survival functions of p38 MAPK is crucial for developing effective therapeutic strategies targeting this pathway.
  • Further research into these less-appreciated roles can inform the clinical application of p38 MAPK inhibitors.