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Platelet-activating factor stimulates motion parameters of cryopreserved human sperm
W J Hellstrom1, R Wang, S C Sikka
1Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana.
Fertility and Sterility
|October 1, 1991
Abstract:
Platelet-activating factor is a naturally occurring molecule that does not appear to cause the detrimental effects to sperm as have been reported for other synthetic stimulatory agents. Incubation of freeze-thawed sperm with low motility with PAF at concentrations greater than or equal to 1.0 microM significantly improved a number of motion parameters (% motility, VSL and LIN). Optimal incubation conditions for PAF were defined at 1 hour and at 25 degrees C. The success of assisted reproductive techniques employing cryopreserved sperm with poor motility may be enhanced by stimulation protocols employing PAF.