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Related Experiment Video

Updated: Jun 26, 2026

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
06:01

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

Published on: July 6, 2017

[BRAF mutation in colorectal serrated lesions].

Zhi-yong Zhou1, Ying Han, Lu-ping Wang

  • 1Department of Gastroenterology, Beijing Military Command's General Hospital, Beijing 100700, China.

Zhonghua Yi Xue Za Zhi
|January 23, 2009
PubMed
Summary

The BRAF V600E mutation is more frequent in serrated colorectal adenocarcinoma and traditional serrated adenoma than in non-serrated adenocarcinoma and villous adenoma. This suggests a distinct serrated neoplasia pathway in colorectal cancer development.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Context:

  • Colorectal cancer (CRC) pathogenesis involves multiple pathways, including the traditional adenoma-carcinoma sequence and a distinct serrated neoplasia pathway.
  • The BRAF V600E mutation is a key driver in various cancers, and its role in serrated colorectal adenocarcinoma (Sca) is under investigation.

Purpose:

  • To determine the frequency of the BRAF V600E mutation in serrated colorectal adenocarcinoma (Sca).
  • To provide indirect evidence for a distinct serrated pathway in colorectal carcinogenesis.
  • To compare BRAF V600E mutation rates across different colorectal lesion types.

Summary:

  • BRAF V600E mutations were detected in 36.4% of Sca and 26.7% of traditional serrated adenoma (TSA) samples.
  • No BRAF V600E mutations were found in non-serrated adenocarcinoma (NS-ca) or villous adenoma samples.

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Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
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Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Published on: July 28, 2010

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Last Updated: Jun 26, 2026

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
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A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

Published on: July 6, 2017

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
28:15

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Published on: July 28, 2010

  • BRAF V600E mutation frequencies were significantly higher in Sca and TSA compared to NS-ca and villous adenoma (P = 0.0084).

    • Impact:

    • Findings support the existence of a separate serrated neoplasia pathway in colorectal cancer, distinct from the traditional adenoma-carcinoma sequence.
    • The study highlights the importance of BRAF V600E mutation analysis in understanding serrated colorectal lesions.
    • This research contributes to the molecular classification of colorectal tumors and may inform future diagnostic and therapeutic strategies.