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[Insulin secretion in nondiabetic manioc consumers]
H Andrianasolo1, M C Fleury-Goyon, A Charrie
1Service de Médecine, Hôpital général, Antananarivo, Madagascar.
Diabete & Metabolisme
|July 1, 1991
Summary
Cassava consumption may alter pancreatic beta cell function, leading to abnormal insulin secretion responses. These changes appear linked to consumption duration, not thiocyanate levels.
Area of Science:
- Endocrinology
- Nutritional Science
- Toxicology
Background:
- Cassava is a staple food for many populations worldwide.
- Cassava contains cyanogenic compounds that can be toxic.
- The impact of long-term cassava consumption on pancreatic beta cell function is not fully understood.
Purpose of the Study:
- To investigate pancreatic beta cell function in healthy individuals consuming cassava.
- To identify potential correlations between cassava consumption patterns and insulin secretion dynamics.
Main Methods:
- Intravenous glucose tolerance test (IVGTT) administered to 28 healthy cassava eaters.
- Comparison of insulin secretion patterns against a control group.
- Analysis of factors including duration of cassava consumption, thiocyanate levels, and genetic data.
Main Results:
- Three distinct insulin secretion patterns were observed: normal, early elevated peak (30 min), and late peak (120 min).
- Abnormal insulin responses occurred without significant increases in blood glucose.
- Abnormalities correlated with the duration of cassava consumption, but not with thiocyanate levels or genetic factors.
Conclusions:
- Cassava consumption may induce alterations in pancreatic beta cell function.
- Cell membrane damage due to cyanogenic components is a potential mechanism.
- Further research is needed to elucidate the precise relationship between cassava intake and metabolic health.