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A High-throughput Method for Measurement of Glomerular Filtration Rate in Conscious Mice
07:07

A High-throughput Method for Measurement of Glomerular Filtration Rate in Conscious Mice

Published on: May 10, 2013

Clinical utility of estimated glomerular filtration rate in patients undergoing gated SPECT

Michele Coceani1, Alessia Gimelli, Clara Carpeggiani

  • 1Fondazione CNR - Regione Toscana Gabriele Monasterio, Via Moruzzi 1, 56124, Pisa, Italy. michecoc@ifc.cnr.it

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
|January 23, 2009
PubMed

Insights

Reduced kidney function (GFR) is linked to coronary artery disease (CAD) and worse outcomes in patients with reversible perfusion defects on g-SPECT scans. Lower GFR predicts CAD and increases mortality risk.

Area of Science:

  • Cardiology
  • Nephrology
  • Nuclear Cardiology

Background:

  • Chronic kidney disease (CKD) is a significant risk factor for coronary artery disease (CAD).
  • Evaluating the relationship between estimated glomerular filtration rate (GFR), CAD presence, and patient prognosis is crucial.

Purpose of the Study:

  • To investigate the association between estimated GFR and the presence of CAD.
  • To assess the prognostic value of GFR in patients with reversible perfusion defects on g-SPECT.

Main Methods:

  • Utilized gated single-photon emission computed tomography (g-SPECT) for myocardial ischemia evaluation.
  • Coronary angiography defined CAD presence (≥70% diameter stenosis).
  • Compared GFR levels and outcomes between patients with and without CAD.

Main Results:

  • Patients with CAD exhibited lower GFR.
  • Reduced GFR (<60 mL/min/1.73 m²) independently predicted CAD.
  • Lower GFR correlated with increased myocardial ischemia extent and higher total and cardiac mortality.

Conclusions:

  • GFR serves as an accurate marker for CAD in patients with positive g-SPECT scans.
  • Reduced GFR is directly correlated with the extent of myocardial ischemia.
  • Diminished GFR negatively impacts survival in this patient cohort.
Abstract

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