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Related Concept Videos

Clinical Trials01:16

Clinical Trials

Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
Case Studies01:22

Case Studies

There are many research methods available to psychologists in their efforts to understand, describe, and explain behavior and the cognitive and biological processes that underlie it.
Clinical Trials: Overview01:11

Clinical Trials: Overview

Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
The Scientific Method02:40

The Scientific Method

Research is what makes the difference between facts and opinions. Facts are observable realities, and opinions are personal judgments, conclusions, or attitudes that may or may not be accurate. In the scientific community, facts can be established only using evidence collected through empirical research.
Data Collection by Experiments01:13

Data Collection by Experiments

Data collection is a systematic method of obtaining, observing, measuring, and analyzing accurate information. An experimental study is a standard method of data collection that involves the manipulation of the samples by applying some form of treatment prior to data collection. It refers to manipulating one variable to determine its changes on another variable. The sample subjected to treatment is known as “experimental units.”
An example of the experimental method is a public clinical trial...
Naturalistic Observations02:30

Naturalistic Observations

If you want to understand how behavior occurs, one of the best ways to gain information is to simply observe the behavior in its natural context. However, people might change their behavior in unexpected ways if they know they are being observed. How do researchers obtain accurate information when people tend to hide their natural behavior? As an example, imagine that your professor asks everyone in your class to raise their hand if they always wash their hands after using the restroom. Chances...

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Related Experiment Video

Updated: Jun 26, 2026

Using Simulation Models to Train Clinicians in the Use of Point-of-Care Ultrasound
05:04

Using Simulation Models to Train Clinicians in the Use of Point-of-Care Ultrasound

Published on: August 9, 2024

More clinical lessons from the FIELD study.

Sergio Fazio1

  • 1Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232-6300, USA. sergio.fazio@vanderbilt.edu

Cardiovascular Drugs and Therapy
|January 23, 2009
PubMed
Summary
This summary is machine-generated.

Fenofibrate treatment in type 2 diabetes patients significantly reduced cardiovascular disease events and showed microvascular benefits, particularly in those with mixed dyslipidemia. The drug was well-tolerated, supporting its use for cardiovascular prevention.

Related Experiment Videos

Last Updated: Jun 26, 2026

Using Simulation Models to Train Clinicians in the Use of Point-of-Care Ultrasound
05:04

Using Simulation Models to Train Clinicians in the Use of Point-of-Care Ultrasound

Published on: August 9, 2024

Area of Science:

  • Cardiology
  • Endocrinology
  • Pharmacology

Background:

  • The Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study involved 9,795 patients with type 2 diabetes.
  • Investigated the impact of fenofibrate on cardiovascular outcomes in this population.

Purpose of the Study:

  • To evaluate fenofibrate's efficacy in reducing cardiovascular events in patients with type 2 diabetes.
  • To assess fenofibrate's impact on microvascular complications and its tolerability.

Main Methods:

  • A large-scale clinical trial (FIELD study) with 9,795 participants.
  • Randomized controlled trial design to assess fenofibrate treatment effects.

Main Results:

  • Fenofibrate showed an 11% relative risk reduction in total cardiovascular disease (CVD) events (p = 0.035).
  • Greater benefits observed in patients with mixed dyslipidemia (triglycerides >2.3 mmol/L, low HDL-C), with a 27% risk reduction (p = 0.005).
  • Significant reductions in laser therapy for retinopathy (30%), non-traumatic amputations (38%), and albuminuria progression (<0.002).

Conclusions:

  • Fenofibrate supports cardiovascular disease prevention in diabetes, especially in patients without prior complications.
  • Fenofibrate may serve as a preventive treatment for diabetic retinopathy.
  • Addition of fenofibrate to statin therapy warrants further investigation in outcome studies.