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The effect of steroids on theophylline absorption
G Tatsis1, D Orphanidou, D Douratsos
1Pulmonary Department, Sotiria Hospital, Athens University, Greece.
The Journal of International Medical Research
|July 1, 1991
Summary
Hydrocortisone did not significantly change plasma theophylline levels in patients with chronic bronchitis or asthma. This study investigated the drug interaction between hydrocortisone and theophylline, finding no significant impact on theophylline concentrations.
Area of Science:
- Pharmacology
- Respiratory Medicine
Background:
- Theophylline is a bronchodilator used for chronic bronchitis and asthma.
- Hydrocortisone is a corticosteroid with anti-inflammatory properties.
- Potential drug interactions between theophylline and hydrocortisone require investigation.
Purpose of the Study:
- To evaluate the effect of hydrocortisone on plasma theophylline concentrations.
- To determine if hydrocortisone administration alters the pharmacokinetics of theophylline in patients with respiratory conditions.
Main Methods:
- 20 patients with chronic bronchitis or stable asthma received oral choline theophyllinate (400 mg) every 12 hours for 8 days.
- Plasma theophylline concentrations were measured every 2 hours.
- Intravenous hydrocortisone (500 mg or 1000 mg) was administered on day 5 or day 7.
Main Results:
- Plasma theophylline concentrations remained largely unchanged after intravenous hydrocortisone administration.
- No statistically significant alterations in theophylline levels were observed.
- Individual patient data showed minimal variability.
Conclusions:
- Hydrocortisone does not appear to significantly affect plasma theophylline concentrations in patients with chronic bronchitis or asthma.
- This finding suggests a lack of significant pharmacokinetic interaction between these two drugs in this patient population.
- Further research may explore other potential clinical implications or interactions.