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Isolation of Primary Human Decidual Cells from the Fetal Membranes of Term Placentae
Published on: April 30, 2018
Decidual immune cell infiltrate in hydatidiform mole
Mahmoud R Hussein1, Ahmad Rezk Abd-Elwahed, Eman Sayed Abodeif
1Departments of Pathology, Assuit University Hospitals, Assuit University, Assuit, Egypt. mrcpath17@gmail.com
Cancer Investigation
|January 23, 2009
Summary
Hydatidiform moles show increased immune cell infiltration in decidual tissue compared to normal pregnancies. This suggests altered maternal immune responses may play a role in hydatidiform mole development.
Area of Science:
- Immunology
- Reproductive Medicine
- Gynecologic Pathology
Background:
- Hydatidiform mole is a gestational trophoblastic disease.
- Complete hydatidiform moles are paternally derived, acting as allografts.
- These allografts can trigger altered maternal immune responses.
Purpose of the Study:
- To investigate the hypothesis that hydatidiform mole development is linked to changes in decidual immune cell populations.
- To quantify immune cell infiltrates in decidual tissue associated with hydatidiform moles and normal pregnancies.
Main Methods:
- Decidual tissue from 30 cases (15 hydatidiform moles, 15 normal first-trimester terminations) were analyzed.
- Immunohistological methods using monoclonal antibodies (CD20, CD68, CD3) identified B cells, histiocytes/dendritic cells, and T cells.
- Immune cell infiltrate counts were compared between the two groups.
Main Results:
- Both normal and molar decidual tissues exhibited immune cell infiltrates.
- Statistically significant increases (p<0.05) in CD20(+) B cells, CD68(+) cells, and CD3(+) T cells were observed in hydatidiform mole decidual tissue compared to normal tissue.
- Specific mean counts showed marked increases in all evaluated immune cell types in the presence of molar changes.
Conclusions:
- Hydatidiform moles are associated with significant numeric alterations in decidual immune cell infiltrates.
- The increased immune cell presence may indicate non-specific or specific immunological processes involved in mole development.
- Further research is needed to explore the pathogenetic and prognostic implications of these immune cell changes.
