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Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

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Related Experiment Video

Updated: Jun 26, 2026

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms
05:00

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms

Published on: March 3, 2021

Cooling therapy for acute stroke.

Heleen M Den Hertog1, H Bart van der Worp, Mei-Chiun Tseng

  • 1Department of Neurology, Erasmus MC University Medical Center, Postbus 2040, Rotterdam, Netherlands, 3000 CA. m.denhertog@erasmusmc.nl

The Cochrane Database of Systematic Reviews
|January 23, 2009
PubMed
Summary

Therapeutic hypothermia, using physical or drug interventions, did not significantly reduce death or dependency in acute stroke patients. Further large clinical trials are needed to evaluate temperature-lowering strategies in stroke care.

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Area of Science:

  • Neurology
  • Critical Care Medicine
  • Clinical Trials

Background:

  • Elevated body temperature is common in acute stroke and linked to poor outcomes.
  • Animal studies show temperature reduction decreases infarct volume in focal cerebral ischemia.
  • Investigating temperature-lowering therapies in acute stroke patients may improve outcomes.

Purpose of the Study:

  • To evaluate the effectiveness of pharmacological and physical methods for reducing body or brain temperature in acute stroke patients.
  • To assess the impact of temperature-lowering strategies on mortality and dependency.
  • To identify potential adverse effects associated with these interventions.

Main Methods:

  • Searched Cochrane Stroke Group trials register, MEDLINE, and EMBASE databases (up to December 2007).
  • Included randomized and non-randomized controlled trials, published or unpublished.
  • Assessed outcomes including death, dependency (modified Rankin Scale score ≥3), and adverse events.

Main Results:

  • Five pharmacological and three physical cooling trials involving 423 participants were included.
  • No statistically significant reduction in death or dependency was observed with either therapy.
  • A non-significant increase in infections was noted for both interventions.

Conclusions:

  • Current evidence from randomized trials does not support the routine use of physical or pharmacological temperature reduction in acute stroke.
  • Larger, well-designed randomized clinical trials are necessary to definitively assess the efficacy of these temperature-lowering strategies.