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Related Experiment Video

Updated: Jun 26, 2026

Murine Ileocolic Bowel Resection with Primary Anastomosis
08:49

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Published on: October 29, 2014

Mechanical bowel preparation for elective colorectal surgery.

Katia K F G Guenaga1, Delcio Matos, Peer Wille-Jørgensen

  • 1Surgical Gastroenterology Department, Ferderal University of São Paulo, Marivaldo Fernandes, 152 apto. 13, Guarujá, São Paulo, Brazil, 11 440-050. kaci@uol.com.br

The Cochrane Database of Systematic Reviews
|January 23, 2009
PubMed
Summary

Mechanical bowel preparation (MBP) before elective colorectal surgery does not significantly reduce anastomotic leakage or wound infections. Current practices should be reconsidered due to a lack of evidence supporting MBP

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Area of Science:

  • Colorectal Surgery
  • Surgical Complications
  • Evidence-Based Medicine

Background:

  • Anastomotic leakage is a risk in colorectal surgery, often linked to bowel content presence.
  • Mechanical bowel preparation (MBP) is widely believed to prevent complications, but this is based on limited data.

Purpose of the Study:

  • To evaluate the safety and effectiveness of MBP in reducing morbidity and mortality in colorectal surgery patients.

Main Methods:

  • Systematic review and meta-analysis of randomized controlled trials (RCTs) comparing MBP with no MBP.
  • Searched MEDLINE, EMBASE, LILACS, and Cochrane Library up to March 2008.
  • Primary outcomes: anastomotic leakage and mortality; Secondary outcomes: infections and reoperations.

Main Results:

  • 13 RCTs with 4777 participants were analyzed.
  • No significant difference in overall anastomotic leakage (4.2% with MBP vs. 3.4% without).
  • No significant difference in wound infection rates (9.6% with MBP vs. 8.3% without).

Conclusions:

  • No statistically significant evidence supports the routine use of MBP before elective colorectal surgery.
  • The necessity of MBP should be re-evaluated.
  • Further research is needed, particularly stratifying for colonic versus rectal surgery.