Related Experiment Video
Updated: Jan 1, 2026

Point-Of-Care Ultrasound Screening for Proximal Lower Extremity Deep Venous Thrombosis
Published on: February 10, 2023
Thrombophilia testing for prevention of recurrent venous thromboembolism
Danny Cohn1, Fleur Vansenne, Corianne de Borgie
1Department of Vascular Medicine, Academic Medical Center Amsterdam, Meibergdreef 9, Room F4-139, Amsterdam, Netherlands, 1105 AZ. d.m.cohn@amc.uva.nl
Background:
Tests for thrombophilia are being performed on a large scale in people after venous thromboembolism (VTE) even though the benefits of testing are still subject to debate. The most important benefit would be a reduction in the risk of recurrent VTE due to the use of additional prophylactic measures.
Objectives:
The objective of this review was to assess the benefit of testing for thrombophilia after VTE in terms of risk reduction of recurrent VTE.
Search Strategy:
The Cochrane Peripheral Vascular Diseases (PVD) Group searched their Trials Register (last searched 15 October 2008) and CENTRAL (last searched The Cochrane Library 2008, Issue 4). We searched MEDLINE, EMBASE, and reference lists.
Selection Criteria:
Randomized controlled trials (RCTs) and controlled clinical trials (CCTs) that compared the rate of recurrent VTE in participants with VTE who were tested for thrombophilia with the rate in participants with VTE who were not tested were eligible.
Data Collection And Analysis:
We planned to extract data from identified studies using data extraction forms.
Main Results:
No studies were included because no RCTs or CCTs could be identified.
Authors' Conclusions:
There are currently no randomized controlled trials or controlled clinical trials that have assessed the benefit(s) of testing for thrombophilia on the risk of recurrent VTE.
Related Concept Videos
Venous Thrombosis IV: Nursing Management
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
Venous Thrombosis III: Interprofessional Care
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies
Venous Thrombosis I: Introduction
Anticoagulant Drugs: Low-Molecular-Weight Heparins

