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Related Concept Videos

Cholecystitis01:20

Cholecystitis

Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...
Endoscopic Procedures V: ERCP01:26

Endoscopic Procedures V: ERCP

Endoscopic Retrograde Cholangiopancreatography (ERCP) is a diagnostic procedure that combines endoscopy and fluoroscopy to diagnose and treat conditions related to the bile ducts, pancreatic ducts, and gallbladder. This procedure is beneficial for identifying and addressing blockages, gallstones, strictures, and tumors within the biliary or pancreatic systems. ERCP is both diagnostic and therapeutic, offering the ability to visualize and treat identified problems in one session.
Patient...
Depolarizing Blockers: Pharmocokinetics01:19

Depolarizing Blockers: Pharmocokinetics

Depolarizing blockers are administered through intravenous injection. Succinylcholine is the most common choice of depolarizing blockers in emergency clinical practices. Although they have a rapid onset, they readily diffuse away from the motor end plate into the extracellular fluid. They are metabolized by enzymes such as liver butyrylcholinesterase and plasma pseudocholinesterases. This produces a short duration of action, typically 5-10 minutes long, unlike nondepolarizing blockers, which...

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Related Experiment Video

Updated: Jun 26, 2026

Laparoscopic Cholecystectomy with Indocyanine Green Fluorescence: Choledochoscopic Stone Extraction and Primary Duct Suture
04:02

Laparoscopic Cholecystectomy with Indocyanine Green Fluorescence: Choledochoscopic Stone Extraction and Primary Duct Suture

Published on: November 25, 2025

Cholecystectomy for suspected gallbladder dyskinesia.

Kurinchi Selvan Gurusamy1, Sameer Junnarkar, Marwan Farouk

  • 1University Department of Surgery, Royal Free Hospital and University College School of Medicine, 9th Floor, Royal Free Hospital, Pond Street, London, UK, NW3 2QG. kurinchi2k@hotmail.com

The Cochrane Database of Systematic Reviews
|January 23, 2009
PubMed
Summary

Cholecystectomy may improve symptoms in patients with gallbladder dyskinesia, but evidence is limited. A single, small trial suggests benefit, but more research is needed to confirm these findings.

Related Experiment Videos

Last Updated: Jun 26, 2026

Laparoscopic Cholecystectomy with Indocyanine Green Fluorescence: Choledochoscopic Stone Extraction and Primary Duct Suture
04:02

Laparoscopic Cholecystectomy with Indocyanine Green Fluorescence: Choledochoscopic Stone Extraction and Primary Duct Suture

Published on: November 25, 2025

Area of Science:

  • Gastroenterology
  • Surgical Innovation
  • Clinical Trials

Background:

  • Biliary dyskinesia treatment remains controversial.
  • Cholecystectomy's efficacy for gallbladder dyskinesia is debated, with conflicting study results.
  • Gallbladder ejection fraction's predictive value for surgical success is uncertain.

Purpose of the Study:

  • To systematically review randomized clinical trials comparing cholecystectomy with no cholecystectomy for suspected gallbladder dyskinesia.
  • To evaluate the benefits and harms of surgical intervention in patients with gallbladder dyskinesia.

Main Methods:

  • Searched major databases (Cochrane, MEDLINE, EMBASE) for relevant randomized clinical trials up to March 2008.
  • Included one high-risk-of-bias trial with 21 patients (11 cholecystectomy, 10 control).
  • Planned intention-to-treat analysis using fixed- and random-effects models.

Main Results:

  • A single trial found significant symptom improvement in all cholecystectomy patients versus one control patient (P = 0.0001) after 33.6 months.
  • No mortality was observed in either group.
  • The trial had a high risk of bias due to lack of blinding and unreported morbidity.

Conclusions:

  • Current evidence on cholecystectomy for gallbladder dyskinesia relies on a single, small, biased trial.
  • Promising results require confirmation through further, well-designed randomized clinical trials.
  • More research with robust bias control is essential to clarify treatment benefits and harms.