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Skin Cancer

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Pigmentation

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Related Experiment Video

Updated: Jun 26, 2026

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

Published on: May 8, 2020

Actinic damage in histopathologically normal skin.

Peter H Bartels¹, Robert S Krouse, Anil R Prasad

¹College of Optical Sciences, University of Arizona, Tucson, Arizona 85724-5024, USA. hubertbartels@msn.com

Analytical and Quantitative Cytology and Histology

|January 24, 2009

Summary

Sun exposure causes detectable skin damage even in histopathologically normal skin. Karyometry, a nuclear measurement technique, can identify these early solar-induced changes.

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Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ

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Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition

Published on: August 18, 2022

Area of Science:

Dermatology
Somatic cell genetics

Background:

Sun exposure is a primary cause of skin aging and cancer.
Early detection of sun damage is crucial for preventative measures.

Purpose of the Study:

To quantify sun damage in histopathologically normal skin.
To assess the utility of karyometry in detecting early solar damage.

Main Methods:

Skin biopsies were collected from areas with varying degrees of sun exposure.
Nuclei from normal skin and actinic keratosis (AK) lesions were analyzed using karyometry.

Main Results:

A progressive increase in skin damage was observed with greater solar radiation exposure.
Karyometry detected statistically significant changes in normal-appearing skin.

Conclusions:

Karyometry can identify sub-clinical skin changes resulting from solar exposure.
This technique offers a method for early detection of sun damage before visible signs appear.