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Related Concept Videos

Epistasis Analysis01:09

Epistasis Analysis

Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
Polygenic Traits01:18

Polygenic Traits

When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
Polygenic Traits01:18

Polygenic Traits

When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Incomplete Dominance01:43

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...

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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

Genetic epidemiology of complex phenotypes.

Lynette Peddle1, Proton Rahman

  • 1Newfound Genomics, St. John's, Canada.

Methods in Molecular Biology (Clifton, N.J.)
|January 24, 2009
PubMed
Summary

Understanding genetic factors in common diseases is crucial. This study reviews the primary methods, linkage and association, for identifying genes contributing to complex traits and diseases.

Area of Science:

  • Genetics
  • Medical Genetics
  • Disease Susceptibility

Background:

  • Genetic factors significantly influence susceptibility to common diseases.
  • Advancements in genetic variant characterization and genotyping enable identification of multiple genes for complex diseases.
  • There is substantial interest in understanding the genetic basis of complex traits.

Purpose of the Study:

  • To review the primary methods for gene identification in complex diseases.
  • To elucidate the design, technical, and statistical considerations of linkage and association analyses.
  • To provide a foundational understanding for researchers in human genetics.

Main Methods:

  • Review of established gene identification methodologies.
  • Discussion of linkage analysis principles and applications.

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In Vivo Modeling of the Morbid Human Genome using Danio rerio
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In Vivo Modeling of the Morbid Human Genome using Danio rerio

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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

In Vivo Modeling of the Morbid Human Genome using Danio rerio
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  • Explanation of association study designs and statistical challenges.

    • Main Results:

    • Linkage analysis identifies genes by tracking inheritance patterns within families.
    • Association studies detect correlations between genetic variants and disease status in populations.
    • Both methods have distinct strengths and limitations for gene discovery.

    Conclusions:

    • Accurate gene identification is essential for understanding complex diseases.
    • Knowledge of linkage and association study designs is critical for effective genetic research.
    • Further research is needed to refine these methods for complex trait analysis.