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[Progressive studies of paeoniflorin].

Li-Rong Sun1, Xiong Cao, Feng-Qing Hou

  • 1Department of Neurobiology, Southern Medical University, Guangzhou 510515, China.

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica
|January 24, 2009
PubMed
Summary

Paeoniflorin, a key compound from Paeonia lactiflora, exhibits diverse pharmacological effects. This review covers its detection, pharmacokinetics, pharmacology, and toxicology, synthesizing current research on this traditional herbal medicine component.

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Area of Science:

  • Pharmacology
  • Natural Products Chemistry
  • Herbal Medicine

Background:

  • Paeoniflorin is a major bioactive monoterpene glucoside isolated from Paeonia lactiflora, a traditional Chinese herbal medicine.
  • First isolated in 1963, paeoniflorin has since been recognized for its numerous pharmacological activities.
  • Research highlights its significance in traditional and modern medicine.

Purpose of the Study:

  • To review current methodologies for detecting paeoniflorin.
  • To summarize existing knowledge on paeoniflorin's pharmacokinetics and pharmacology.
  • To present an overview of the toxicology of paeoniflorin.

Main Methods:

  • Literature search of PubMed and National Knowledge Infrastructure Data Base.
  • Synthesis of recent research findings on paeoniflorin.

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  • Review of studies focusing on detection, pharmacokinetics, pharmacology, and toxicology.

    • Main Results:

    • Established detection methodologies for paeoniflorin.
    • Detailed understanding of paeoniflorin's absorption, distribution, metabolism, and excretion (pharmacokinetics).
    • Comprehensive overview of its diverse pharmacological actions and toxicological profile.

    Conclusions:

    • Paeoniflorin possesses significant pharmacological potential.
    • Further research is warranted to fully elucidate its therapeutic applications and safety profile.
    • This review consolidates current knowledge, providing a foundation for future studies on paeoniflorin.