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Published on: November 4, 2010
Exploring the distal lung: new direction in asthma.
1Department of Medicine, National lewish Health, Denver CO 80206, USA. martinr@njc.org
The Israel Medical Association Journal : IMAJ
|January 24, 2009
Summary
Ultrafine inhaled steroid particles improve asthma control by reaching distal airways. This review examines airway changes, physiology, and clinical outcomes related to particle size in asthma therapy.
Area of Science:
- Respiratory Medicine
- Pulmonology
- Pharmacology
Background:
- Asthma affects airways extending to alveolar tissue.
- Current inhaled asthma therapies often have large particle sizes, limiting distal airway deposition.
- Difficult-to-control asthma may benefit from improved distal airway treatment.
Purpose of the Study:
- To review anatomic and physiological changes in distal airways in asthma.
- To analyze clinical outcome data related to distal airway treatment.
- To evaluate the impact of inhaled preparation particle size on asthma management.
Main Methods:
- Review of pathohistological, physiological, and clinical studies.
- Analysis of data on inhaled medication particle size and deposition.
- Examination of studies using ultrafine particles for asthma therapy.
Main Results:
- Ultrafine inhaled steroid particles reach peripheral airways.
- Demonstrated improvement in air trapping and symptomatic outcomes with ultrafine particles.
- Large particle medications primarily deposit in central and medium airways.
Conclusions:
- Particle size is a critical factor in inhaled asthma therapy effectiveness.
- Ultrafine particles offer a promising approach for treating distal airway disease in asthma.
- Targeting distal airways with appropriate particle sizes can enhance asthma control.
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