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Related Experiment Videos

Antigen presentation in acquired immunological tolerance.

D C Parker1, E E Eynon

  • 1Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01655.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|October 1, 1991
PubMed
Summary

Acquired tolerance can be induced by specific unresponsiveness instead of memory. Small B lymphocytes may act as antigen-presenting cells, causing inactivation and contributing to self-tolerance by preventing autoimmune responses.

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Area of Science:

  • Immunology
  • Transplantation Immunology
  • Autoimmunity

Background:

  • Acquired tolerance involves specific unresponsiveness following antigen exposure, contrasting with immunological memory.
  • Mechanisms of self-tolerance in T and B lymphocytes are crucial for preventing autoimmunity.
  • Clonal anergy, or lymphocyte inactivation, may result from incomplete antigen presentation lacking accessory signals.

Purpose of the Study:

  • To investigate the role of small, resting B lymphocytes in acquired tolerance.
  • To explore the potential of B lymphocytes as antigen-presenting cells in inducing tolerance.
  • To understand how anergic B and T lymphocytes might contribute to self-tolerance and prevent autoimmunity.

Main Methods:

  • The study proposes a mechanism involving B lymphocytes as antigen-presenting cells.

Related Experiment Videos

  • Focuses on the lack of accessory signals required for T lymphocyte activation.
  • Examines the consequences of antigen receptor engagement without full co-stimulation.

    • Main Results:

    • Small, resting B lymphocytes are proposed as inactivating antigen-presenting cells in acquired tolerance.
    • B lymphocytes can efficiently gather and process low-concentration antigens via their receptors.
    • Anergic B and T lymphocytes may function as suppressor cells, blocking autoimmune responses.

    Conclusions:

    • B lymphocytes play a significant role in acquired tolerance to proteins and class II transplantation antigens.
    • B lymphocytes may be critical in maintaining self-tolerance by inducing anergy in autoreactive lymphocytes.
    • Persisting anergic lymphocytes could act as regulatory cells, preventing autoimmune diseases.