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Ten years of rizatriptan: from development to clinical science and future directions
Richard J Hargreaves1, Chris R Lines, Alan M Rapoport
1Merck Research Laboratories, West Point, PA, USA.
Abstract:
The year 2008 marked the 10th anniversary since rizatriptan was first launched for the acute treatment of migraine. In this article we discuss the concepts that motivated the preclinical and clinical development of rizatriptan, the clinical evidence that has driven its use over the past decade, rizatriptan's overall contribution to the field, and future directions for research.
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