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Updated: Jun 26, 2026

Cox-Maze IV Procedure Concomitant with Valvular Surgery In Situs Inversus Dextrocardia: A Single-Center Experience in China
Published on: February 11, 2022
Improved patient survival with concomitant Cox Maze III procedure compared with heart surgery alone
Yves Louagie1, Michel Buche, Philippe Eucher
1Cardiovascular Department, Université Catholique de Louvain, Cliniques Universitaires de Mont-Godinne, Yvoir, Belgium. louagie@chir.ucl.ac.be
Insights
The Cox Maze III procedure combined with heart surgery significantly improves long-term survival for patients with persistent atrial fibrillation. This cardiac surgery approach reduces mortality from heart failure and sudden death.
Area of Science:
- Cardiology
- Cardiac Surgery
- Electrophysiology
Background:
- The Cox Maze procedure is a surgical treatment for atrial fibrillation.
- Its long-term efficacy when combined with heart surgery requires evaluation.
Purpose of the Study:
- To assess the long-term benefit of the Cox Maze III procedure combined with heart surgery.
- To compare survival rates in patients who underwent combined surgery versus heart surgery alone.
Main Methods:
- A retrospective study comparing 37 patients (Maze group) with 66 controls.
- All patients had persistent atrial fibrillation preoperatively.
- Follow-up data was analyzed for survival and rhythm conversion.
Main Results:
- Five-year survival was 89% in the Maze group vs. 60% in the control group (p=0.008).
- The Maze procedure independently improved survival (p=0.019) and reduced deaths from heart failure and sudden death.
- Five-year conversion to sinus rhythm was 91% in the Maze group vs. 33% in controls (p<0.001).
Conclusions:
- Combining the Cox Maze procedure with heart surgery significantly enhances long-term survival.
- Restoration of sinus rhythm is a key factor in improved outcomes.
- The procedure is particularly beneficial for patients with enlarged left atria.
Background:
The benefit of the Cox Maze procedure combined with heart surgery was evaluated at long-term follow-up.
Methods:
The outcome for 37 patients who underwent a Cox Maze III procedure combined with heart surgery (Maze group) was compared with that of 66 patients who had heart surgery alone (control group). All patients were in persistent atrial fibrillation preoperatively. The two groups had similar preoperative characteristics and were operated upon during the same era (1996 to 2004).
Results:
Five-year survival, including hospital deaths, was 89% +/- 5% in the Maze group and 60% +/- 7% in the control group (log rank p = 0.008). Causes of death were predominantly related to heart failure (1 of 37 in the Maze group and 12 of 66 in the control group; p = 0.02) and to sudden death (0 of 37 in the Maze group and 9 of 66 in the control group; p = 0.02). After correction for preoperative variables, Cox regression analysis showed that the Maze procedure improved survival independently (p = 0.019). In a subgroup of patients with left atrial diameter of more than 60 mm preoperatively, the 5-year survival estimate was 92% +/- 6% in the Maze group versus 59% +/- 9% in the control group (log rank p = 0.012). The 5-year estimate of conversion to sinus rhythm was 91% +/- 7% in the Maze group and 33% +/- 7% in the control group (log rank p < 0.001).
Conclusions:
The restoration of sinus rhythm by a Maze procedure combined with heart surgery markedly improved long-term survival in this series.
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