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Quantitative Proteomics Workflow using Multiple Reaction Monitoring Based Detection of Proteins from Human Brain Tissue
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Matrix metalloproteinases and their multiple roles in neurodegenerative diseases

Gary A Rosenberg1

  • 1Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131-0001, USA. grosenberg@salud.unm.edu

The Lancet. Neurology
|January 24, 2009
PubMed

Insights

Matrix metalloproteinases (MMPs) and ADAMs play key roles in neuroinflammation and neurodegenerative diseases. Inhibiting MMPs may offer novel therapeutic strategies for neurological conditions.

Area of Science:

  • Neuroscience
  • Biochemistry
  • Pathology

Background:

  • Matrix metalloproteinases (MMPs) and ADAMs are implicated in neuroinflammation.
  • Their roles in neurodegenerative disorders are increasingly recognized.
  • Tissue inhibitors of metalloproteinases (TIMPs) regulate MMP activity.

Purpose of the Study:

  • To review the role of MMPs in neuroinflammation and neurodegenerative diseases.
  • To explore the mechanisms by which MMPs affect neurological function.
  • To discuss potential therapeutic strategies targeting MMPs.

Main Methods:

  • Literature review of studies on MMPs, ADAMs, and neuroinflammation.
  • Analysis of MMP involvement in blood-brain barrier permeability and tissue repair.
  • Examination of MMP/ADAM roles in Alzheimer's and Parkinson's diseases.

Main Results:

  • MMPs increase blood-brain barrier permeability, leading to edema and cell death.
  • MMPs contribute to angiogenesis and neurogenesis in tissue repair.
  • MMPs and ADAMs are linked to amyloid processing and dopaminergic neuron loss.

Conclusions:

  • MMPs are significant contributors to neuroinflammation and neurodegeneration.
  • Targeting MMPs with inhibitors presents a promising therapeutic avenue for neurological diseases.

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