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Age-related differences in the pathogenesis of calcific aortic stenosis: the potential role of resistin

Dania Mohty1, Philippe Pibarot, Jean-Pierre Després

  • 1Laboratoire d'Etudes Moléculaires des Valvulopathies, Groupe de Recherche en Valvulopathies, Quebec Heart Institute/Hôpital Laval Research Center, Department of Surgery, Laval University, Quebec, Canada.

International Journal of Cardiology
|January 24, 2009
PubMed

Insights

Elderly patients with aortic stenosis have less atherogenic lipid profiles but higher resistin levels, which correlate with valve calcification and inflammation, suggesting age-related factors beyond lipids contribute to AS.

Area of Science:

  • Cardiovascular Medicine
  • Metabolic Research
  • Geriatric Cardiology

Background:

  • Aortic stenosis (AS) is linked to atherosclerosis, but its pathophysiology in the elderly remains unclear.
  • Investigating age-specific metabolic determinants of valvular inflammation and calcification in AS is crucial.

Purpose of the Study:

  • To compare the metabolic profiles of elderly and younger patients with severe aortic stenosis.
  • To determine the association between plasma adipokines, lipid profiles, and valvular characteristics in elderly AS patients.

Main Methods:

  • Analyzed plasma lipid profiles and adipokine levels (resistin, leptin) in 114 patients undergoing aortic stenosis surgery.
  • Quantified aortic valve calcification and inflammation in relation to metabolic markers.

Main Results:

  • Elderly patients (>70 years) exhibited lower LDL-C, reduced small LDL particles, and larger HDL particle size.
  • Increased plasma resistin and leptin levels were observed in elderly patients compared to younger ones.
  • Higher plasma resistin correlated significantly with increased aortic valve calcification and inflammation in the elderly.

Conclusions:

  • The lipid profile in elderly AS patients is less atherogenic than in middle-aged individuals.
  • Elevated resistin levels in older adults with AS are associated with valvular calcification and inflammation.
  • Age-related changes in resistin may play a role in the development of aortic stenosis, independent of traditional lipid-driven atherosclerosis.
Abstract

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