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Updated: Jun 26, 2026

Strand-Specific Analysis of Proteins at Replicating DNA Strands by Enrichment and Sequencing of Protein-Associated Nascent DNA Method
Published on: May 2, 2025
Insights into the cellular role of enigmatic DNA polymerase iota
Antonio E Vidal1, Roger Woodgate
1Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Armilla, Granada, Spain.
Abstract:
It has been a decade since the discovery of human DNA polymerase iota (poliota). Since that time, the enzyme has been characterized extensively at the biochemical level, but the cellular function of poliota remains enigmatic. Recent studies on poliota have, however, provided much needed insights into its biological role(s) and suggest that the enzyme plays important functions in protecting humans from the deleterious consequences of exposure to both oxidative- and ultraviolet light-induced DNA damage.
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