In vivo tumor detection on rabbit with biopsy needle as MRE driver

Magnetic Resonance Elastography (MRE) is a phase contrast imaging technique to quantitatively measure the elasticity of tissues. Typically, the oscillating driver is placed on the surface of objects to generate shear waves. When it is applied to detect tumors in deep location, the depth penetration of the wave is limited by attenuation and the biopsy procedure has to be performed separately. In this study, we describe a method using biopsy needle as the MRE driver to produce shear waves in tissues. We made comparison between the MRE acquisitions obtained with biopsy needle and surface drivers. Because the well-defined propagation wave pattern reduces the error in wavelength calculation, the acquisitions of biopsy needle driver shows better homogeneity in stiffness map. We also performed the experiment with the biopsy needle for in vivo tumor detection in rabbits. This study demonstrates that the biopsy needle driver is more effective than the surface driver for accurately measuring the stiffness and location of the tumor.