Related Experiment Video
Updated: Jun 26, 2026

Multi-system Monitoring for Identification of Seizures, Arrhythmias and Apnea in Conscious Restrained Rabbits
Published on: March 27, 2021
Regional differences in rabbit atrial action potential properties: mechanisms, consequences and pharmacological
Oleg V Aslanidi1, Rebecca S Dewey, Alexandra R Morgan
1School of Physics and Astronomy, University of Manchester, Manchester, M13 9PL, United Kingdom. oleg.aslanidi@manchester.ac.uk
Abstract:
Regional differences in electrical action potential (AP) properties can provide a substrate for atrial arrhythmias. We quantify such differences by developing detailed AP models for the left (LA) and right (RA) rabbit atrial cells in order to study the underlying electrophysiological mechanisms, as well as their impacts on vulnerable properties of the atrial tissue. The transient outward current, Ito, is identified as the major factor contributing to the AP differences between the LA and RA cells, which suggests a potential pharmacological target for reducing heterogeneity and vulnerability of the atria.
Related Concept Videos
Electrophysiology of Normal Cardiac Rhythm
Antiarrhythmic Drugs: Class II Agents as β-Adrenergic Blockers
Cardiac Action Potential
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
Mechanism of Cardiac Arrhythmias
ECG Interpretation of Arrhythmias II: Atrial, Junctional and Ventricular Arrhythmias
Action Potential
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...

