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Non-symmetrical double-logistic analysis of 24 hour arterial stiffness profile in normotensive and hypertensive

D Bia1, R Armentano, F Pessana

  • 1Physiology Department, School of Medicine, Republic University, General Flores 2125, PC: 11800, Montevideo, Uruguay. dbia@fmed.edu.uy

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
|January 24, 2009
PubMed

Insights

Arterial stiffness (AS) follows an asymmetric daily pattern, with higher levels at night. This pattern differs between healthy individuals and untreated hypertensive subjects, who exhibit greater AS and blood pressure variations.

Area of Science:

  • Cardiovascular Physiology
  • Chronobiology
  • Hypertension Research

Background:

  • The circadian rhythm of cardiovascular events (CE) is not fully understood.
  • The relationship between daily changes in arterial stiffness (AS) and CE requires investigation.
  • Standardized methods for measuring circadian profiles of cardiovascular variables are lacking.

Purpose of the Study:

  • To characterize the circadian pattern of arterial stiffness (AS).
  • To analyze day-night and night-day transitional changes in AS.
  • To compare AS patterns in untreated hypertensive (HG) and normotensive (NG) subjects using a novel mathematical model.

Main Methods:

  • Employed a non-symmetrical six-parameter double-logistic model for analysis.
  • Conducted 24-hour ambulatory recordings of blood pressure (BP), heart rate (HR), and pulse transit time (PTT(AB)) and velocity index (PTV(AB)).
  • PTT(AB) and PTV(AB) served as inverse and direct measures of AS, respectively.

Main Results:

  • The double-logistic model effectively characterized the circadian pattern of AS.
  • Demonstrated an asymmetric circadian profile for AS in humans for the first time.
  • Observed higher AS levels during nighttime in both normotensive and hypertensive groups.

Conclusions:

  • Arterial stiffness exhibits an asymmetric circadian pattern that differs between healthy and hypertensive individuals.
  • Hypertensive subjects displayed significantly higher AS levels and greater blood pressure variability.
  • Hypertensive individuals showed less pronounced changes in AS during transitional periods (day-night and night-day).
Abstract

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