Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Healthcare professionals' perspectives on prescribing DOACs to frail older patients; the DOAC-FRAIL questionnaire.

BMC geriatrics·2026
Same author

Sex-Differences in Post-Procedural Pain Experiences After Thermal Liver Ablations for Liver Tumors: A Retrospective Study.

Cardiovascular and interventional radiology·2024
Same author

Modulation of fungal biofilm physiology and secondary product formation based on physico-chemical surface properties.

Bioprocess and biosystems engineering·2019
Same author

Real-world study on clinical outcomes of nucleos(t)ide analogues antiviral therapy in patients with chronic hepatitis B.

Epidemiology and infection·2019
Same author

A straightforward method for quantification of vinyl functionalized water soluble alginates via <sup>13</sup>C-NMR spectroscopy.

International journal of biological macromolecules·2019
Same author

Performance and precision of double digestion RAD (ddRAD) genotyping in large multiplexed datasets of marine fish species.

Marine genomics·2018
Same journal

Analysis of End-Tidal CO2 Variability During Plateau Waves Episodes: An Information Theoretic Approach<sup></sup>.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

AI and Tomosynthesis for Breast Cancer Molecular Subtyping: A step toward precision medicine<sup></sup>.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

Towards Sustainable Protein Recovery from Biological Waste: Assessing Polyethersulfone-based Microfiltration.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

Analysis of the cardiovascular response to standardized polymicrobial peritonitis experimental model.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

Automated Wrist Ultrasound Image Bone Enhancement and Segmentation Using Deep Learning.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

A Deep Learning approach for Depressive Symptoms assessment in Parkinson's disease patients using facial videos.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
See all related articles

Related Experiment Video

Updated: Jun 26, 2026

Fabrication of Magnetic Platforms for Micron-Scale Organization of Interconnected Neurons
09:54

Fabrication of Magnetic Platforms for Micron-Scale Organization of Interconnected Neurons

Published on: July 14, 2021

Peptide-functionalized microfabricated structures for improved on-chip neuronal adhesion.

B Van Meerbergen1, K Jans, J Loo

  • 1Dept. of Chemistry of the KU Leuven, Flemish Institute of Biotechnology (VIB), Belgium. bart.vanmeerbergen@imec.be

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
|January 24, 2009
PubMed
Summary
This summary is machine-generated.

Researchers developed peptide-functionalized self-assembled monolayers (SAMs) on structured sensors. This surface engineering promotes cell adhesion and tight coupling for improved electrogenic cell recordings.

More Related Videos

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits
10:32

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits

Published on: April 15, 2015

Interfacing 3D Engineered Neuronal Cultures to Micro-Electrode Arrays: An Innovative In Vitro Experimental Model
09:47

Interfacing 3D Engineered Neuronal Cultures to Micro-Electrode Arrays: An Innovative In Vitro Experimental Model

Published on: October 18, 2015

Related Experiment Videos

Last Updated: Jun 26, 2026

Fabrication of Magnetic Platforms for Micron-Scale Organization of Interconnected Neurons
09:54

Fabrication of Magnetic Platforms for Micron-Scale Organization of Interconnected Neurons

Published on: July 14, 2021

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits
10:32

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits

Published on: April 15, 2015

Interfacing 3D Engineered Neuronal Cultures to Micro-Electrode Arrays: An Innovative In Vitro Experimental Model
09:47

Interfacing 3D Engineered Neuronal Cultures to Micro-Electrode Arrays: An Innovative In Vitro Experimental Model

Published on: October 18, 2015

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Cellular Neuroscience

Background:

  • High signal-to-noise ratio extracellular recordings from electrogenic cells depend on close cell-electrode coupling.
  • Existing methods struggle to achieve consistent and stable tight coupling between cells and sensor surfaces.

Purpose of the Study:

  • To develop novel surface chemistry and topography strategies for enhanced cell-electrode coupling.
  • To investigate the role of peptide-functionalized self-assembled monolayers (SAMs) in promoting cell adhesion and engulfment.

Main Methods:

  • Fabrication of micro- and nano-structured sensor surfaces.
  • Assembly of alkanethiol-based self-assembled monolayers (SAMs) functionalized with specific peptides.
  • Characterization of cell adhesion, outgrowth, and coupling using focused ion beam scanning electron microscopy (FIB-SEM) and confocal fluorescence imaging.

Main Results:

  • Optimized peptide concentration on SAMs significantly influenced cell adhesion and outgrowth.
  • The combination of peptide-functionalized SAMs and structured surfaces induced a phagocytosis-like engulfment mechanism.
  • This engulfment resulted in demonstrably tighter coupling between electrogenic cells and the sensor surface.

Conclusions:

  • Peptide-functionalized SAMs on structured surfaces provide a robust strategy for achieving tight cell-electrode coupling.
  • The observed phagocytosis-like event is a key mechanism for enhancing recording quality in electrogenic cells.
  • This approach holds significant potential for improving extracellular recording technologies.