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In Vitro Multiparametric Cellular Analysis by Micro Organic Charge-modulated Field-effect Transistor Arrays

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Published on: September 20, 2021

Novel neuromorphic CMOS device array for biochemical charge sensing.

Santosh Pandey¹, Michelle Daryanani, Baozhen Chen

¹Department of Electrical and Computer Engineering, Iowa State University, Ames, IA, USA.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

|January 24, 2009

Summary

A novel umbrella-shaped field-effect transistor (UGFET) enhances biochemical charge sensing. This neuromorphic CMOS device offers improved scalability and sensitivity for large-array applications.

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Area of Science:

Neuromorphic Engineering
Biochemical Sensing
Solid-State Devices

Background:

Existing field-effect transistor (FET) based charge sensors face limitations in scalability and sensitivity.
There is a need for advanced sensor designs for large-array biochemical detection.

Purpose of the Study:

To propose and validate a novel neuromorphic CMOS device, the umbrella-shaped FET (UGFET), for enhanced biochemical charge sensing.
To improve sensor scalability and sensitivity for potential large-array applications.

Main Methods:

Modification of the extended floating-gate FET architecture to create the UGFET.
3-D device simulations to validate the UGFET model.
Fabrication of the UGFET in a standard CMOS process and experimental characterization.

Main Results:

The UGFET design demonstrates a maximized charge sensing area within a reduced transistor footprint.
Experimental results show improved scalability and sensitivity compared to previous chemoreceptive FET sensors.
Successful biochemical charge sensing was achieved using transconductance and subthreshold measurement schemes.

Conclusions:

The UGFET represents a significant advancement in neuromorphic CMOS biochemical charge sensors.
The UGFET design is suitable for large-array applications, offering enhanced performance.
This work validates the UGFET's potential for sensitive and scalable biochemical detection.