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Updated: Jun 26, 2026

A Computational Modeling Approach to Investigate the Influence of Hyperthermia on the Tumor Microenvironment
Published on: December 1, 2023
FFT-based computation of the bioheat transfer equation for the HCC ultrasound surgery therapy modeling
Jean-Louis Dillenseger1, Simon Esneault, Carole Garnier
1INSERM, U642, Rennes, France. jean-louis.dillenseger
Abstract:
This paper describes a modeling method of the tissue temperature evolution over time in hyperthermia. More precisely, this approach is used to simulate the hepatocellular carcinoma curative treatment by a percutaneous high intensity ultrasound surgery. The tissue temperature evolution over time is classically described by Pennes' bioheat transfer equation which is generally solved by a finite difference method. In this paper we will present a method where the bioheat transfer equation can be algebraically solved after a Fourier transformation over the space coordinates. The implementation and boundary conditions of this method will be shown and compared with the finite difference method.
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