Related Experiment Video
Updated: Jun 26, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Applying time, frequency and nonlinear features from nocturnal oximetry to OSA diagnosis
Daniel Alvarez1, Roberto Hornero, J Victor Marcos
1Biomedical Engineering Group, E.T.S. Ingenieros de Telecomunicación, University of Valladolid, Camino del Cementerio s/n, Valladolid, Spain. dalvgon@ribera.tel.uva.es
Abstract:
This study is aimed to improve the diagnostic ability of blood oxygen saturation (SaO(2)) in obstructive sleep apnea (OSA) detection. We studied 74 patients suspected of suffering from OSA. Ten characteristics were derived from each SaO2 recording: arithmetic mean, variance, skewness and kurtosis from both time and frequency domains, central tendency measure and Lempel-Ziv complexity. The diagnostic ability of each feature was assessed by means of a receiver operating characteristics (ROC) analysis. Additionally, forward stepwise logistic regression (LR) was applied. The kurtosis in the time domain and the nonlinear measure of complexity were automatically selected. This methodology reached 93.2% sensitivity, 80.0% specificity and 87.8% accuracy, improving the results from each feature individually. Our study showed that common statistics in the time and frequency domains and nonlinear features could provide additional and complementary information to help in OSA diagnosis.
Related Concept Videos
Pulse Oximetry
Purpose
Average SpO2 values are greater than 95%. If the readings fall below 90%, it indicates that...
Sleep Apnea
The condition is more prevalent among...
Special considerations while measuring oxygen saturation
Ensuring accuracy in vital sign recordings while prioritizing patient comfort and minimizing anxiety is important.
Guidelines For Measuring Vital Signs
Before taking a patient's vital signs, a nurse would consider and assess the patient's comfort level and ensure appropriate equipment is available.
Pulse rhythm
Conversely, an irregular pulse pattern is termed dysrhythmia, stemming from disruptions in cardiac muscle...
Sleep-Wake Cycles
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:

