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Updated: Jun 26, 2026

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice
Published on: May 10, 2019
On the synthesis of multiple frequency tone burst stimuli for efficient high frequency auditory brainstem response
Roger M Ellingson1, Marilyn L Dille, Marjorie R Leek
1National Center for Rehabilitative Auditory Research (NCRAR), VA Medical Center, 3710 SW US Veterans Hospital Road, Portland, OR 97207, USA. Roger.Ellingson@med.va.gov
Abstract:
The development and digital waveform synthesis of a multiple-frequency tone-burst (MFTB) stimulus is presented. The stimulus is designed to improve the efficiency of monitoring high-frequency auditory-brainstem-response (ABR) hearing thresholds. The pure-tone-based, fractional-octave-bandwidth MFTB supports frequency selective ABR audiometry with a bandwidth that falls between the conventional click and single-frequency tone-burst stimuli. The MFTB is being used to identify high frequency hearing threshold change due to ototoxic medication which most generally starts at the ultra-highest hearing frequencies and progresses downwards but could be useful in general limited-bandwidth testing applications. Included is a Mathcad implementation and analysis of our MFTB synthesis technique and sample performance measurements of the MFTB stimulus configuration used in a clinical research ABR system.
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