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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...

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Related Experiment Videos

Chemotherapy side-effect management using mobile phones.

Mark E Larsen1, Joanna Rowntree, Annie M Young

  • 1Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, OX3 7DQ, UK.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
|January 24, 2009
PubMed
Summary
This summary is machine-generated.

A new telemedicine system using mobile phones helps patients report chemotherapy side effects from home. This system alerts nurses to severe symptoms, enabling timely intervention for better colorectal cancer patient care.

Related Experiment Videos

Area of Science:

  • Oncology
  • Medical Informatics
  • Digital Health

Background:

  • Colorectal cancer is a leading cause of mortality in developed nations.
  • Home-based chemotherapy delivery poses challenges for timely side-effect monitoring.
  • Effective patient-reported outcome measures are crucial for managing treatment toxicity.

Purpose of the Study:

  • To evaluate a novel telemedicine system for monitoring chemotherapy side effects in colorectal cancer patients.
  • To assess the system's ability to facilitate early detection and reporting of adverse events.
  • To explore the feasibility of mobile-phone-based symptom diaries in home-care oncology.

Main Methods:

  • Development of a mobile-phone-based telemedicine system for patient symptom diaries.
  • System implementation for six colorectal cancer patients undergoing oral chemotherapy.
  • Alerting system for nurses triggered by patient-reported severe side effects.
  • Data collection on symptom progression and intervention.

Main Results:

  • The system successfully enabled patients to report symptoms remotely.
  • Two instances of moderate symptoms escalating to severe conditions were identified.
  • Timely alerts allowed for the provision of individualized self-care and treatment advice.
  • The system demonstrated potential for real-time adverse event management in home chemotherapy settings.

Conclusions:

  • Telemedicine systems can enhance the monitoring of chemotherapy side effects in the home setting.
  • Mobile health platforms offer a viable solution for improving patient-reported outcome capture in oncology.
  • Early detection of symptom deterioration through telemedicine can facilitate prompt clinical intervention, improving patient safety and outcomes.